(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid
NIGERICIN SODIUM SALT
CAS: 28380-24-7
Molecular Formula: C40H68O11
(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid - Names and Identifiers
(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid - Physico-chemical Properties
| Molecular Formula | C40H68O11 |
| Molar Mass | 724.96 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Melting Point | 183.5-185° |
| Boling Point | 779.9±60.0 °C(Predicted) |
| Solubility | chloroform: 10 mg/mL, clear, colorless |
| pKa | 4.39±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Bioactive Nigericin is an antibiotic derived from Streptomyces hygroscopicus, which can act as an ionophore (K /H ionophore) and promote K /H exchange across mitochondrial membranes. Nigericin can induce IL-1β release in a NALP3-dependent manner and can be used as an NLRP3 activator. Nigericin triggers the decline of red blood cells, which occurs simultaneously with the formation of ROS, partly due to the induction of oxidative stress. Nigericin induces apoptosis (apoptosis). |
| Use | Use Nigeria is a polycyclic ether carboxylic acid compound, its role is mainly to exchange hydrogen ions and potassium ions. |
(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
| UN IDs | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | QT6840000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29419090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned) |
(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid - Uses and synthesis methods
overview
Similar to the formation of a complex of diaminase and potassium ions, the negatively charged carboxylate of Nigerian bacterin interacts with cations to form a Nigerian bacterin-potassium ion complex, which performs hydrogen ion-potassium ion exchange.
Target
K /H ionophore
Last Update：2024-04-09 21:01:54
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